Lymph-node metastases in patients with melanoma: what is the optimum management?
Identifieur interne : 009B50 ( Main/Exploration ); précédent : 009B49; suivant : 009B51Lymph-node metastases in patients with melanoma: what is the optimum management?
Auteurs : Kate Fife [Royaume-Uni] ; John F. Thompson [Australie]Source :
- Lancet Oncology [ 1470-2045 ] ; 2001.
Abstract
Lymph-node metastasis is an indicator of poor prognosis for patients with melanoma. The management of regional nodes is controversial, with continuing debate about whether surgery or radiotherapy of positive lymph nodes improves longterm survival or whether nodal involvement is merely a marker of aggressive disease. However, there is general agreement that systemic chemotherapy is rarely an effective form of management. This review therefore considers surgical and radiotherapeutic aspects of lymph-node management in patients with melanoma. We discuss regional control and survival after lymphnode surgery in retrospective series, randomised trials of elective lymph-node dissection, the role of sentinel lymph-node biopsy, radiobiology and radiotherapy fractionation issues in melanoma treatment, retrospective studies of adjuvant nodal radiotherapy, and finally, randomised trials of adjuvant radiotherapy after lymph-node dissection.
Url:
DOI: 10.1016/S1470-2045(01)00519-8
Affiliations:
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